NEXVIGILANT INTELLIGENCE

Applying the 5-phase clinical trial methodology — Preclinical through Post-Market Surveillance — to software validation. ICH E2A principles for code quality.

Cross-drug comparison of semaglutide, liraglutide, and metformin. 5/18 dimensions identical where pharmacology demands identity, 13/18 correctly differentiated.

A framework for understanding how systems persist through correction. Eight laws governing boundary, state, feedback, and identity — from pharmacovigilance to software architecture.

A governance framework mapping golf's three ground axioms — state acceptance, boundary respect, and proportional judgment — to system design and decision-making.

PRR 17.39, 4/4 disproportionality measures positive, PROBABLE causality (Naranjo 5). The GLP-1 RA class reference signal for pancreatitis.

PRR 71.42 — the strongest signal tested. Naranjo 6 (PROBABLE). Boxed Warning yet benefit-risk ratio 435.9 FAVORABLE.

Six axioms derive special relativity and E=mc² using only boundary, state, and causality primitives. A bilinear metric plus Noether's theorem produces mass-energy equivalence.

The 15-step pharmacovigilance pipeline materialized as a 25mm × 40mm microfluidic device. Each microgram decision tree becomes a physical channel, valve, or detection chamber.

Multi-source pharmacovigilance signal investigation for semaglutide and pancreatitis. PRR 6.93, 4/4 disproportionality measures positive, POSSIBLE causality.

A lifecycle model for ideas — from the Guardian Angel protocol to temporal compounding. How sessions metabolize time into persistent capability through ATP-like energy cycles.

How a single molecular pathway simultaneously proves BET inhibitor efficacy and causes their dose-limiting toxicity via the GATA1/NFE2/PF4 megakaryopoiesis pathway.

The conservation law is structurally isomorphic to the derivative. All four pharmacovigilance disproportionality measures are the same equation with different boundary operators.