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6-Step Signal Investigation Pipeline
NexVigilant Station Demo
A complete pharmacovigilance signal investigation using 2958 free tools across 20 million+ FAERS reports. Every number below was computed live by NexVigilant Station — not asserted from training data.
PRR, ROR, IC, and EBGM are not four independent tests. They are a single conservation law evaluated with four different boundary operators. They share the same 2×2 contingency table. They differ only in how they measure departure from the expected.
| Drug + Event | Reports | PRR(≥2.0) | ROR(CI>1) | IC(>0) | EBGM(≥2) | Naranjo | Signal |
|---|---|---|---|---|---|---|---|
Semaglutide Pancreatitis (2017) | 2,068 | 6.93 | 7.09 | 2.76 | 6.76 | 4/13POSSIBLE | SIGNAL DETECTED |
Liraglutide Pancreatitis (2010) | 3,219 | 17.39 | 18.53 | 4.06 | 16.67 | 4/13POSSIBLE | SIGNAL DETECTED |
Atorvastatin Rhabdomyolysis (1996) | 2,226 | 4.79 | 4.83 | 2.20 | 4.58 | 4/13POSSIBLE | SIGNAL DETECTED |
Metformin Lactic Acidosis (1995) | 18,417 | 71.42 | 74.58 | 4.83 | 28.44 | 6/13PROBABLE | SIGNAL DETECTED |
Semaglutide was approved December 2017. The PRR spiked to 11.3 in 2020 (small-denominator effect), then converged to 6.9 as the Wegovy obesity indication massively expanded the prescribing base. The signal was detected in every single year — never borderline.
All four disproportionality measures are instances of a single equation:
| Metric | Boundary Operator | Scale | Null Value | What It Adds |
|---|---|---|---|---|
| PRR | ratio = a/(a+b) / c/(c+d) | Linear | 1.0 | Raw departure |
| ROR | odds = ad/bc | Odds | 1.0 | Prevalence correction |
| IC | info = log2(O/E) | Bits | 0.0 | Information surprise |
| EBGM | bayes = posterior/prior | Bayesian | 1.0 | Sample size trust |
You don't run four tests. You run one equation four ways. The metrics agree on direction (signal or not) but disagree on magnitude — because each boundary adds a different form of epistemic caution.
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Data: FAERS (20M+ reports), OpenVigil France, DailyMed, PubMed, RxNav, ClinicalTrials.gov
Verified by NexVigilant Station (2958 public tools). Signal data computed March 26, 2026. Tool count refreshed daily.