Benefit-Risk Assessment — QBRI & QBR
Quantitative benefit-risk assessment tools. Two complementary families: QBRI (expert-judgment, 7-variable formula) and QBR (statistical-evidence from contingency tables using PRR/ROR/IC/EBGM). Include
6 toolsbenefit-risk
Compute Qbri
Compute the Quantitative Benefit-Risk Index (QBRI) from benefit and risk parameters. QBRI = (B × Pb × Ub) / (R × Pr × Sr
benefit_effectbenefit_pvalueunmet_needrisk_signalrisk_probabilityrisk_severity
Derive Qbri Thresholds
Derive optimal QBRI decision thresholds (tau_approve, tau_monitor, tau_uncertain) from historical FDA drug approval deci
no params
Qbri Equation
Get the QBRI equation with variable definitions and hypothesis thresholds. Reference tool — explains what each term mean
no params
Compute Qbr
Compute full statistical benefit-risk ratio from contingency tables using disproportionality analysis (PRR/ROR/IC/EBGM).
methodbenefit_tablesrisk_tables
Compute Qbr Simple
Quick benefit-risk ratio from one benefit and one risk contingency table. Returns the B/R ratio, individual signal stren
methodbenefit_tablerisk_table
Compute Therapeutic Window
Compute therapeutic window from efficacy and toxicity dose-response curves using Hill equation integration. Returns the
efficacytoxicity