PV Decision Trees
Atomic pharmacovigilance decision trees (micrograms): sub-microsecond PV logic for signal classification, causality routing, seriousness assessment, and regulatory action. Chains compose multiple micr
33 toolsmicrogram
Run Pv Signal To Action
Run the core PV workflow chain: PRR signal detection → causality bridge → Naranjo assessment → regulatory action routing
prrnaranjo_scoreis_serious
Run Case Assessment Pipeline
Run the complete case assessment chain: case validity → seriousness classification → causality evidence → regulatory act
prrnaranjo_scoreis_serious
Run Benefit Risk Assessment
Run the benefit-risk assessment chain: weighs therapeutic benefit against safety risk using PRR, Naranjo, NNH, and thera
prrnaranjo_scoreis_serious
Run Prr Signal
Classify a PRR value as signal/no-signal using Evans (2001) criteria. PRR >= 2.0 = signal.
prr
Run Naranjo Quick
Quick Naranjo causality assessment from a score. Returns causality category (DEFINITE/PROBABLE/POSSIBLE/DOUBTFUL) with c
naranjo_score
Run Case Seriousness
Classify case seriousness per ICH E2A criteria. Returns seriousness category, expedited reporting requirement, and deadl
is_serious
Run Workflow Router
Route a PV case to the appropriate workflow based on case characteristics. Returns workflow type, priority, and first ac
is_serious
List Micrograms
List all available micrograms with their descriptions and test counts.
no params
List Chains
List all available microgram chains with their step sequences.
no params
Run Station Dailymed Pipeline
DailyMed ADR label data → risk tier → causality routing. Pipe get-adverse-reactions output fields directly into this cha
has_boxed_warninghas_remsserious_reactions_counttotal_reactions_count
Run Station Pubmed Pipeline
PubMed signal literature → evidence strength → causality routing. Pipe search-signal-literature output into this chain t
total_articlescase_report_countsystematic_review_countrecent_counthas_regulatory_citation
Run Station Openvigil Pipeline
OpenVigil disproportionality → signal triage → causality routing. Pipe compute-disproportionality output fields into thi
prrprr_ci_lowerrorror_ci_lowericcase_count
Run Station Trial Pipeline
Clinical trial SAE data → safety concern triage → causality routing. Pipe compare-trial-arms or get-serious-adverse-even
treatment_sae_ratecontrol_sae_ratetotal_saeshas_deathsphase
Run Station Drugbank Pipeline
DrugBank DDI data → interaction severity → causality routing. Pipe get-interactions output into this chain to get a clin
interaction_countcyp_inhibitionnarrow_ti_involved
Run Station Rxnav Pipeline
RxNav drug interaction data → interaction severity → signal routing. Pipe get-interactions output into this chain to cla
interaction_counthas_contraindicationhas_serioushas_moderate
Run Station Recall Pipeline
FDA recall data → recall severity classification → regulatory action routing. Pipe search-recalls or get-recall-classifi
recall_classis_ongoingdistribution_scope
Run Seriousness To Deadline
ICH E2A seriousness classification → boolean decomposition → deadline routing. Input the 6 ICH E2A seriousness criteria
deathhospitalizationdisabilitylife_threateningcongenital_anomalymedically_important
Run Adr Severity Escalation
ADR CTCAE grading → escalation routing. Classify adverse drug reaction severity using CTCAE-aligned criteria and get the
is_fatal
Run Confidence Deadline
Assessment confidence level → reporting urgency classification. Given an assessment confidence score and days until repo
confidencedeadline_days
Run Investigation Prioritization
Transbeyesian class propagation → EIG priority ranking. For a drug-event signal, determines whether to investigate direc
source_prrsignal_thresholdtransfer_weightprior_strengthuncertainty_levelextremity_levelpropagation_count
Run Signal Deep Validation
Multi-dimensional signal quality assessment. Combines 4 disproportionality measures (PRR/ROR/IC/EBGM), validates criteri
prr_signalror_signalic_signalebgm_signalprr_above_thresholdcase_count_sufficientgeographic_spreadtemporal_patternprr_currentpct_changeoccurrence_countprior_action_taken
Run Bradford Hill Evidence
Bradford Hill evidence assessment: signal comparison → dose-response classification → Naranjo causality. A 3-criterion c
signal_asignal_blow_dose_ratemid_dose_ratehigh_dose_ratenaranjo_score
Run Bradford Hill Multi Criterion
Full 5-criterion Bradford Hill causality assessment: temporal association → signal comparison → dose-response → rechalle
drug_start_to_event_daysevent_before_drugsignal_asignal_bthresholdlow_dose_ratemid_dose_ratehigh_dose_ratebaseline_ratefirst_exposure_raterechallenge_ratenaranjo_score
Run Crystalbook 4Primitive
Crystalbook 4-Primitive Conservation Check: assess whether a system conserves Existence (∃), Boundary (∂), State (ς), an
no params
Run Crystalbook 8Law
Crystalbook 8-Law Risk Matrix: assess virtue scores (0-10) for each of the 8 Laws of System Homeostasis. Scores 7+ = SAT
no params
Run Crystalbook Diagnostic
Crystalbook Full Diagnostic: combines 4-primitive conservation check + law triage into a single diagnostic. Returns cons
no params
Run Ich Q1A Stability Testing
ICH Q1A(R2) Stability Testing decision tree. Given product type, storage type, and accelerated study outcome, returns st
product_typestorage_type
Run Ich Q1B Photostability
ICH Q1B Photostability Testing decision tree. Encodes the Decision Flow Chart: directly exposed → immediate pack → marke
product_type
Run Ich E1 Population Exposure
ICH E1 Population Exposure decision tree. Routes minimum safety database size for drugs intended for long-term treatment
treatment_durationcondition_severity
Run Heligram
Helix Computing decision tree — encode any system through the conservation law ∃ = ∂(×(ς, ∅)). Given boundary sharpness
boundarystatevoid
Run Sota Drift Detection
Guardian SOTA Tracker — detect frontier movement in a pharmacovigilance domain. Classifies the PV domain (signal detecti
domainevidence_levelauthority_weightnovelty_score
Run Sota Authority Decompose
Decompose threshold authority into primitives — consensus breadth, credential strength, evidence basis, institutional ba
consensus_levelcredential_strengthevidence_basisinstitutional_backing
Run Sota Pubmed Pipeline
PubMed → SOTA pipeline: triage a publication for frontier relevance, classify its PV domain, check frontier movement, an
article_typepub_yeardomainnovelty_score