Pharmacokinetics
PK modeling, drug clearance computation, ADME parameters, and drug interaction profiling
15 toolspharmacokinetics
Clearance Config
Clearance Config
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Clearance Evaluate
Evaluate a gate operation (access, write, or external call) against classification policy.
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Clearance Level Info
Get metadata and predicates for a specific classification level.
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Clearance Policy For
Get the enforcement policy for a specific classification level.
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Clearance Validate Change
Validate a classification change (upgrade or downgrade).
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Drug Class Members
List all drugs in the catalog that belong to the given drug class.
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Drug Compare
Compare safety profiles of two drugs using per-event PRR comparison.
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Drug Profile
Get the complete drug profile including signals, indications, and label status.
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Drug Signals
Get all safety signals for a drug with PRR/ROR/IC values.
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Pk Auc
the terminal elimination phase where concentrations decay exponentially.
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Pk Clearance
For IV: F = 1.0. For oral: F < 1.0 reflects first-pass metabolism.
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Pk Half Life
Clinically: ~4–5 half-lives to reach steady state or eliminate drug.
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Pk Ionization
Critical for predicting absorption (stomach vs intestine) and renal excretion.
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Pk Michaelis Menten
When [S] >> Km: zero-order (rate ≈ Vmax, capacity-limited).
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Pk Steady State
Reached after ~4–5 half-lives. Used to verify therapeutic window compliance.
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